At present, the etiology of both benign and malignant soft tissue tumors is not clear, and it is mainly believed to be related to genetic factors, radiological factors, environmental factors, immune factors and other factors. 1. Genetic factors: some patients develop the disease, which may have a certain relationship with genetic factors. Especially those with family history of the disease, the incidence rate is higher than that of normal people, but the mechanism is not clear. 2. Radioactive factors: a history of exposure to radiation or radioactive materials may lead to an increased risk of the disease. 3. Environmental factors: prolonged exposure to polluted environments can also increase the probability of soft tissue tumors. 4. Immunologic factors: Some people believe that this disease may also be related to immunodeficiency, but there is no conclusive evidence or exact mechanism to prove it. 5. Other factors: other factors such as scarring, injury and viral infection may also induce soft tissue tumors. The etiology of this disease is not clear, once diagnosed, one should seek medical examination as soon as possible and follow the doctor’s instructions for treatment.