Children’s toothache in the middle of the night crying all night, may be due to dental caries, pulpitis and other factors, different causes of different treatment, including general treatment, medication, and treatment of the cause. 1. General treatment: For more severe pain, acetaminophen or ibuprofen tablets can be used under the guidance of a doctor to relieve pain. 2. Medication: If bacterial infection is identified, azithromycin, cefaclor, etc. can be taken orally to fight infection. 3. Treatment of causes: Different causes of toothache are treated differently. (1) Dental caries: If the toothache is caused by dental caries, resin filling can be performed to avoid the carious part of the tooth from stimulating the nerve leading to toothache. (2) Pulpitis: If caries or other reasons have caused changes in the dentin, or even invaded the nerve of the tooth, you can open the pulp drainage or root canal surgery. Root canal treatment mainly involves removing the nerve and pulp of the tooth and preserving the rest of the tooth. If your child has a toothache in the middle of the night and cries all night, there may be other reasons, so it is recommended that you consult a doctor in time to find out the cause and treat the cause of the toothache.