The causes of low cholesterol are as follows: First, liver diseases, when the liver cells are severely damaged clinically, it may cause a decrease in the synthesis of the enzyme necessary for cholesterol synthesis, 3-hydroxy-3-methylglutaric acid monoacyl coenzyme A, thus causing a decrease in total serum cholesterol; Second, endocrine diseases, such as hyperthyroidism and Addison’s disease can cause low total cholesterol; Third, severe anemia, such as aplastic anemia, hemolytic anemia, iron deficiency anemia and malnutrition anemia can cause low cholesterol; fourth, diseases of abnormal lipid metabolism, like hypocholesterolemia and alpha lipoprotein deficiency can make low cholesterol. The above content is for reference only, please refer to the doctor’s face-to-face guidance for specific medication and treatment.