If the toenail thickening, it is likely to be a fungal infection caused by gray nails, usually manifested as yellowish thickening of the nails, the majority of patients will also be accompanied by symptoms of tinea pedis, need to go to the hospital dermatology department to do a smear test clear. If the problem is caused by fungal infection, you can choose drugs for standardized antifungal treatment, at present the general choice of combined treatment, on the one hand, local application, terbinafine hydrochloride cream and other antifungal ointment topical application; on the other hand, you also need to combine oral antifungal drugs, such as voriconazole, the treatment needs to be at least 4-6 months of time, a long period of time oral voriconazole may affect liver function, so pay attention to monitoring, in addition to the oral voriconazole, the liver function is also very important, the liver function is also very important. Therefore, it is important to monitor, in addition to consider the use of encapsulation therapy.