A positive WT-1 generally means that there are residual leukemia cells in the organism.WT-1 can be used as an indicator to monitor residual disease, but the test varies from laboratory to laboratory, so a trend value of WT1 is more valuable clinically.
WT-1 is an acronym for Wilms tumor gene, which is located on chromosome 11 and has the primary function of recognizing and binding specific target DNA and regulating transcription.
When performing blood laboratory tests, WT-1 positivity is a predictive indicator of residual foci of blood tumors, indicating that there are still leukemia cells in the organism. It is recommended that patients go to regular hospitals for further flow cytology, chromosome and other tests, and if it suggests that there is a relapse or residual foci need further treatment.
After complete remission of leukemia treatment, the tiny residual lesions should be detected regularly. Even if the leukemia is in complete remission, treatment should be continued with regular MRD testing, and the treatment method, regimen, and duration of treatment should be adjusted according to the MRD level in order to achieve a cure. If this leukemia is positive for tiny residual lesions, it indicates that the patient needs further chemotherapy treatment.
WT-1 positivity should go to regular hospitals, clarify the cause of the disease with the help of the doctor, and use medication under the doctor’s guidance, do not take medication on your own.