Metastasis of intramesenteric lymph nodes suggests that the tumor cells have metastasized and proliferated, and it is necessary to improve the prognosis of the disease through radiotherapy, chemotherapy and targeted therapy in time. After the metastasis of intramesenteric lymph nodes, the primary tumor can be surgically resected and lymph node dissection can be carried out. It is also necessary to reduce the tumor foci and inhibit the spread of tumor metastasis through active radiotherapy, chemotherapy and targeted therapy, so as to improve the quality of life of the patients. The chemotherapy drugs that patients can choose include 5-fluorouracil, cyclophosphamide, paclitaxel and so on; targeted drugs include bevacizumab, cetuximab and so on. Drugs are recommended to strictly follow the doctor’s instructions for standardized use, not unauthorized use of drugs, adverse reactions to drugs should be timely consultation, drug allergy is prohibited. By actively cooperating with doctors to receive standardized treatment, can significantly improve the prognosis of the disease.