Sodium bicarbonate can be used in the treatment of gynecological conditions, mainly in clinical practice as an adjunct to the treatment of vulvovaginal pseudomonal yeast disease caused by Candida infection. The pathogen of vulvovaginal pseudomonal yeast disease is Pseudomonas aeruginosa, also known as Candida albicans. Pseudomonas aeruginosa is suitable for growth in an acidic environment and its vaginal pH is usually less than 4.6. Sodium bicarbonate is an alkaline drug, and diluting the sodium bicarbonate solution and douching the vagina or taking a sitz bath can make the vagina alkaline and thus inhibit the reproduction of Pseudomonas aeruginosa. However, when sodium bicarbonate is used to treat vulvovaginal pseudomycosis, vaginal antifungal drugs are also used. Because sodium bicarbonate only inhibits the growth of bacteria but does not kill them, treatment with medications such as miconazole nitrate suppositories or mycophenolate vaginal suppositories is also needed. When diluting the sodium bicarbonate solution, it must be prepared according to medical advice and the concentration should not be too high to avoid damaging the vaginal mucosa. In addition, women should avoid spicy and stimulating food in their daily life, pay attention to rest, avoid staying up late, and enhance their physical fitness and immunity through moderate exercise.