Most patients with pancreatic cancer are already in advanced stage when diagnosed, and only 10% of them have the chance of surgery, and the treatment effect of chemotherapy is very unsatisfactory. In recent years, the use of chemotherapy combined with targeted therapy has improved the efficacy, but it is still unsatisfactory and expensive. The main goal of treatment for patients with advanced pancreatic cancer is to reduce symptoms and improve the quality of survival. Our hospital mainly adopts a comprehensive treatment method combining Chinese medicine with minimally invasive treatment (high-energy ultrasound focused knife, radiofrequency, interventional therapy, heat therapy, etc.), chemotherapy and targeted therapy for advanced pancreatic cancer, and designs the corresponding individualized treatment plan according to the patient’s specific situation. Hepatome (high-energy ultrasound focusing knife) is a minimally invasive physical therapy that kills tumors through high-energy ultrasound focusing technology, and has certain therapeutic effects on controlling the development of local lesions and reducing clinical symptoms such as pain.