Pain after lumbar puncture can be treated with bed rest and oral pain medication. Lumbar puncture operation with thicker puncture needles causes some damage to the lumbar muscle ligaments and other tissues, which will cause pain in the lower back after the puncture operation. You can choose bed rest to reduce the lumbar muscle ligaments and other tissues pulling, and promote the repair of damage to relieve pain. If the pain is more obvious, you can take non-steroidal anti-inflammatory analgesic drugs to relieve pain, such as diclofenac sodium, celecoxib and so on. When getting out of bed after lumbar puncture surgery, you can also wear a lumbar immobilization belt to reduce the pressure on the lumbar spine and relieve pain. If pain occurs after lumbar puncture surgery, it is recommended that patients go to the hospital to improve the examination and receive regular treatment.