Toothache and eye pain may be pulpitis, maxillofacial tumors, trigeminal neuralgia, etc. Symptoms can be relieved by adjusting work and rest, oral pain medication, and surgery. 1. Most of the eye pain caused by toothache is due to inflammation of the dental nerve, which is also called pulpitis, and the pain is characterized by spontaneous, paroxysmal pain, scattered, and can be radiated to the same side of the head, ear, and temporal area, so the attack of pulpitis will be accompanied by eye pain and headache at the same time. At this time, you can adjust the work and rest, usually pay attention to a light diet, do not eat too cold or too hot food, to avoid the stimulation of the teeth, if serious, oral anti-inflammatory drugs such as aspirin to relieve pain. 2. Maxillofacial tumors can be benign and malignant, and the tumor can compress the oral cavity and eyeballs, thus producing pain. If the sinus opening of maxillary sinus is blocked, causing the accumulation of mucus in the sinus cavity, it will lead to maxillary sinus cyst, which will compress the gums downward to cause toothache, and extrude upward to cause headache and eyeball pain. After diagnosis, we need to observe the size and location of the tumor and whether it has metastasized to decide the treatment mode. Benign ones can be surgically removed, and malignant ones can be treated by surgery plus postoperative radiotherapy to maintain the treatment. 3. When trigeminal neuralgia causes ophthalmic and maxillary branches of trigeminal nerve, there will be eye pain, toothache and facial pain, and the pain is characterized by trigger points, which will be triggered by brushing teeth, eating and blowing cold wind, and it is necessary to take medicines under the guidance of doctors for symptomatic and causative treatments, for example, Carbamazepine tablets, Phenytoin sodium tablets, and so on. If accompanied by fever, nasal congestion, severe facial pain need to promptly identify the cause of the appropriate treatment.