Cold ankles may be caused by physiological factors such as localized cold, or by pathological factors such as thromboembolic vasculitis and diabetic foot. 1. Physiological factors: when the weather is cold, through the short pants, resulting in the ankle exposed to the cold air. At this time, the ankle area will appear cold performance, which is a normal physiological phenomenon, usually after paying attention to keep warm local symptoms will improve. 2. Thromboembolic vasculitis: the cause of thromboembolic vasculitis is not clear, and it is considered to be related to smoking. There may be a decrease in the skin temperature of the affected limbs, limb weakness, intermittent claudication and other symptoms, and patients may show cold ankles and wrists. 3. Diabetic foot: diabetic foot is due to diabetic peripheral neuropathy, diabetic vasculopathy. It often manifests itself in abnormal foot sensation, foot deformity, low foot skin temperature, etc., so the patient will have the symptom of cold ankles and wrists. If the symptoms continue to be unrelieved, you should go to the hospital in time and choose the appropriate measures for treatment under the guidance of the doctor.