Do you need the hepatitis B vaccine? The hepatitis B vaccine is mainly given to newborns, followed by infants and children, unimmunized people under 15 years of age and high-risk groups (e.g., medical personnel, people who have frequent contact with blood, people who work in childcare facilities, organ transplant patients, people who receive frequent blood transfusions or blood products, people who are immunocompromised, family members of HBsAg-positive people, men who have sex with men, people who have multiple sexual partners and people who inject drugs intravenously). ). People who have been infected with hepatitis B virus, even if they do not produce surface antibodies and only have core and/or E antibodies, may not be vaccinated against hepatitis B. Even if they are vaccinated against hepatitis B, they may not be able to produce surface antibodies. How long is the protection period of hepatitis B vaccine? The duration of protection for those who have antibodies after hepatitis B vaccination generally lasts at least 12 years. The general population does not need anti-HBs monitoring or booster immunization. However, anti-HBs monitoring can be performed in high-risk groups, and booster immunization can be given if anti-HBs is <10 mIU/mL.