Lung nodules 25 millimeters without burrs, in most cases, suggests benign possibility; if the nodule exists and continues to grow, malignant possibility cannot be excluded. Lung nodules 25 mm without burrs may be inflammatory lung nodules, tuberculosis nodules, benign lung tumors, hemangiomas, etc., usually without clinical symptoms, but need to pay attention. Inflammatory nodules need antibiotic treatment, tuberculosis nodules need anti-tuberculosis treatment; benign tumors for this size of nodules recommend early surgery to prevent malignant transformation; hemangioma, with the risk of rupture, surgery is recommended. When lung nodules 25 mm combined with burr signs, unclear borders, irregular nodule shape, most consider malignant changes, need to be early hospitalization and receive appropriate treatment. Lung nodules 25 mm without burrs are recommended to visit the hospital in time for further treatment under the guidance of specialized doctors.