Small blisters on the palms of the hands is very itchy may be due to sweat herpes, tinea versicolor, contact dermatitis and other factors, need to clarify the cause of the symptomatic treatment, common treatment drugs are tacrolimus ointment, clotrimazole, cetirizine and so on. 1. Sweat herpes: is a symmetrical occurrence in the palms of the hands, soles of the feet, fingers and other parts of the blistering dermatosis, typical lesions are slightly above the skin surface of the small blisters, can be accompanied by burning, itching, and so on. Local use of tacrolimus ointment, mometasone furoate cream and other drugs, itching intense oral cetirizine, imipramine extended-release tablets and other drugs. 2. ringworm: due to dermatophyte infection, manifested as erythema, blisters, scales, itching and other symptoms, can be used externally clotrimazole, miconazole, naftifine and other medications, when the condition is serious, can be taken orally terbinafine, itraconazole, and other antifungal drug treatment. 3. Contact dermatitis: due to contact with lacquer, soap and other exogenous substances caused by skin inflammatory reaction, manifested as erythema, papules, blisters may appear in severe cases, accompanied by itching. Zinc oxide oil, hydrocortisone cream and other drugs can be used to apply local, itching severe oral benadryl, and avoid re-exposure to allergens. Small blisters on the palm of the hand is very itchy may also be caused by other factors, it is recommended that patients seek medical attention in a timely manner, clear causes under the guidance of the doctor for standardized treatment, avoid self-medication, so as not to delay the condition.