Cerebrospinal fluid leakage is usually considered in postoperative patients with pituitary tumors who experience symptoms such as clear, watery nasal discharge and loss of sense of smell, which is aggravated by bowel movements and coughing. Pituitary tumors are benign tumors originating from the pituitary gland, and cerebrospinal fluid leakage refers to defects at the base of the skull due to trauma or medical injury. Usually, the presence of cerebrospinal fluid leakage after pituitary tumor surgery is determined by the combination of clinical symptoms and external factors. Cerebrospinal fluid leakage should be considered when there is continuous or intermittent discharge of clear watery fluid from the nasal cavity, mostly from one side of the nose, accompanied by symptoms such as loss of sense of smell, nausea, vomiting, fever, headache, etc., which can be aggravated by the increase of intracranial pressure due to straining to defecate, coughing, sneezing, breath-holding, and bowing down of the head. In conclusion, postoperative management of pituitary tumor patients should be strengthened, and the presence of the above symptoms should be promptly reported to the doctor for standardized treatment.