The difference between trazodone and sertraline mainly lies in the different drug components, different indications, different adverse reactions and different contraindications. 1. Different drug components: Trazodone is mainly trazodone hydrochloride, belonging to the triazolopyridine class of antidepressants; sertraline is sertraline hydrochloride, a selective 5-hydroxytryptamine reuptake inhibitor, the two are different drugs. 2. Different indications: Trazodone is mainly applied to various types of depression and anxiety disorders with depressive symptoms and mood disorders after withdrawal of drug-dependent people; Sertraline is used to treat symptoms related to depression, including depression with or without a history of mania, accompanied by anxiety and depression, and can also be used for the treatment of obsessive-compulsive disorder. 3. Different adverse reactions: Trazodone adverse reactions include drowsiness, fatigue, dizziness, headache, insomnia, nervousness, tremor, dry mouth, blurred vision, etc.; Sertraline adverse reactions include insomnia, dizziness, headache, somnolence, diarrhea, nausea, anxiety, depressive symptoms. 4. Contraindications are different: in addition to allergy to drug components prohibited, severe heart disease, severe impairment of liver function, impaired consciousness, cardiac arrhythmia prohibited trazodone; and sertraline contraindications are relatively few, allergic to the product and the components contained in the person prohibited, prohibited and monoamine oxidase inhibitors, pimozide co-prescription. Trazodone and sertraline need to follow the doctor’s instructions when using medication, not to self-medication.