Sertraline does not have a role in the treatment of prostatitis, it is recommended that patients with prostatitis follow the doctor’s instructions for full dosage and full course of medication. Sertraline is an antidepressant that is mainly used to treat symptoms associated with depression, such as anxiety, mania, etc. After satisfactory treatment, continuing to take sertraline can effectively prevent the recurrence of depression, sertraline can also be used for the treatment of obsessive-compulsive disorder, but there is no therapeutic effect on prostatitis. Medications for prostatitis include antimicrobials such as ofloxacin, cephalosporin, azithromycin, etc. For patients with localized pain, non-steroidal anti-inflammatory drugs such as celecoxib can be used, and medications such as tamsulosin can be used to relax the muscles of the prostate gland in order to improve the symptoms of pain or obstructive urination. Patients should use the medication in full dosage and course, and should not stop or increase or decrease the dosage of the medication without authorization, so as not to affect the therapeutic effect of the medication. Adverse reactions such as fever, hypertension and abdominal pain can occur in some patients when using sertraline. Patients with prostatitis should use the drug under the guidance of a doctor, and should not blindly use sertraline for treatment, in order to avoid serious discomfort, delayed condition, and even other serious adverse effects.