The sudden death of Ma Ji, the great comic leader of the generation, and the untimely death of Hou Yuewen, a comic artist, made people lament and ponder that although with the development of medical technology, modern medicine has many effective treatments for coronary heart disease, from century-old aspirin to new antithrombotic drugs represented by Bolivet and low-molecular heparin, from traditional old nitroglycerin to beta-blockers, ACEI and From traditional nitroglycerin to beta-blockers, ACEI and statin lipid-lowering drugs, from drug treatment to interventional surgery and coronary artery bypass grafting represented by intracoronary stenting, countless patients with coronary artery disease have been given a new lease of life. These remedial treatment measures after the onset of coronary artery disease, although “it is never too late to mend the fold”, are not satisfactory due to the irreparable damage caused by coronary artery disease and the fact that many people are too late to receive treatment in the hospital and have accidents outside the hospital. Therefore, how to achieve early prevention and treatment of coronary heart disease and prevent the occurrence of coronary heart disease has been the current concern of the medical and health sectors. It is recognized that the prevention of coronary heart disease is not enough in the past, only focus on the treatment after the onset of the disease, many people have low awareness of the main risk factors of coronary heart disease, low treatment rate, low control rate of the “three low” situation. Only by controlling coronary heart disease at its source can the occurrence of coronary heart disease be truly reduced. Coronary heart disease is caused by the interaction of various environmental and genetic factors, and is a preventable and treatable disease. Studies have shown that risk factors such as advanced age, hypertension, diabetes, hyperlipidemia, and smoking are closely associated with the risk of developing coronary heart disease. Recent findings also suggest that nine major risk factors, including abnormal ApoB to ApoA ratio (ApoB/ApoA-1), smoking, diabetes, hypertension, abdominal obesity, psychological factors such as stress and depression, reduced exercise, poor dietary habits and alcohol use, predict the risk of myocardial infarction in 90% of men and 94% of women, all of which can be be modified. Of particular concern is that in recent years, with the early intervention of multiple risk factors for coronary heart disease, the incidence of coronary heart disease in developed countries such as Europe and the United States has shown a decreasing trend. However, with the rapid socio-economic development in China, lifestyle-related factors such as people’s dietary structure, physical activity intensity, and psychosocial stress are gradually developing in an unfavorable direction, and the incidence of major risk factors such as hypertension, hyperlipidemia, and diabetes is increasing year by year. On the other hand, the effective control of risk factors is lagging far behind that of developed Western countries. Among the 160 million hypertension and 160 million hyperlipidemia patients, there is a low awareness rate, low treatment rate and low compliance rate, and the number of obese people is gradually increasing and the number of smokers remains high. Therefore, active and effective early intervention of risk factors for the development of coronary heart disease in our population is the first task to reduce the risk of coronary heart disease. In addition to the application of risk factors to predict the risk of coronary heart disease, the detection of preclinical lesions of atherosclerotic disease is also an important tool for the early prevention and treatment of coronary heart disease. Preclinical atherosclerotic disease is defined as a condition in which there is evidence of atherosclerosis but no significant atherosclerotic stenosis of important arteries (e.g., coronary, cerebral, renal, and peripheral arteries) leading to clear clinical symptoms, also known as subclinical atherosclerotic lesions. Atherosclerotic disease is a chronic, progressive disease, and scientific studies have shown that it starts in childhood and adolescence. A significant proportion of patients are asymptomatic until the onset of acute cardiovascular events such as acute myocardial infarction and stroke. Therefore, screening for high-risk individuals who already have significant atherosclerotic lesions is a more effective and acceptable means of early prediction of coronary heart disease through non-invasive screening methods to understand changes in vascular function or vessel wall conditions before the patient develops obvious clinical manifestations of coronary heart disease. Some of the commonly used international technical methods to assess early atherosclerotic lesions include carotid intima-media thickness, ankle-arm index and pulse wave velocity, which can be easily measured by ultrasound and atherosclerosis detector. Medical studies suggest that these indicators correlate with the risk of developing coronary heart disease. Once clinical evidence of atherosclerosis is detected through these non-invasive tests, it can draw the attention of patients and doctors to enhance the control of risk factors associated with coronary heart disease. Of course, there are no further intervention methods for this group of people other than risk factor control, which is currently being explored by the medical community. We are also studying whether certain drugs such as statins, which are clearly effective for patients with diagnosed coronary heart disease, and intensive lifestyle interventions can slow down the development of atherosclerosis in this population with the support of the national “Eleventh Five-Year Plan” science and technology research project. Currently, the incidence of hypertension, hyperlipidemia, hyperglycemia and other three highs is still rising, and the prevalence of poor lifestyle and psychological conditions such as smoking, alcoholism, sedentary lifestyle, car-based walking, high-fat fast food diet, and stress caused by fast-paced work life, it is expected that the incidence of atherosclerotic diseases represented by coronary heart disease will continue to increase in China in the near future, so the comprehensive prevention and treatment of coronary heart disease is particularly important. Therefore, the comprehensive prevention and treatment of coronary heart disease is particularly important. The prevention and treatment from the source of coronary heart disease is undoubtedly a way to get twice the result with half the effort. As long as we pay attention to the cause of coronary heart disease prevention and treatment itself, to achieve early knowledge of atherosclerosis, so as to carry out targeted prevention and treatment, I believe that people will be able to overcome coronary heart disease.