Brucellosis is a natural epidemic disease caused by Brucella, which can be treated with antibacterial (doxycycline and rifampicin, etc.), antipyretic and analgesic (acetaminophen, etc.), adrenocorticotropic hormone (dexamethasone, etc.), and immunomodulatory (levofloxacin, etc.) medications according to the patient’s specific symptoms and the specific treatment plan and dosage should be in accordance with the doctor’s instructions. 1. Antibacterial drugs: commonly used drugs include doxycycline and rifampicin, sulfonamides, such as methotrexate, etc. The specific treatment plan and drug dosage should be in accordance with the doctor’s instructions. 2. Antipyretic and analgesic: patients with high fever can be treated with antipyretic and analgesic, such as aspirin, acetaminophen and so on. 3. Adrenocorticotropic hormone: If the symptoms of systemic poisoning are serious, adrenocorticotropic hormone can be used appropriately, such as dexamethasone, hydrocortisone for treatment. 4. Immunomodulators: such as commonly used leucovorin, transfer factor, etc., can regulate the body’s immunity and accelerate the improvement of the disease. Once brucellosis occurs, it is important to pay attention to timely hospitalization and reasonable treatment under the guidance of the doctor.