There are differences between Down’s syndrome screening and non-invasive DNA in terms of testing cycle, test coverage and accuracy. 1. Screening cycle: Down’s syndrome screening is usually performed between 16-18 weeks of pregnancy, while non-invasive DNA testing can be performed between 12-22 weeks. 2. Scope of testing: Both tests are able to estimate the risk of trisomy 21, trisomy 18, trisomy 13, and neural tube malformations, and non-invasive DNA can be used to check for more items in some institutions. 3. Data accuracy: Down’s screening is relatively less accurate than non-invasive DNA testing. It is recommended to choose between Down’s syndrome screening and non-invasive DNA testing under the guidance of your doctor according to your actual situation and data needs.