Homocysteine 18 requires folic acid supplementation. Homocysteine 18 is out of the normal range and is on the high side. It is mainly due to the fact that the enzyme that catalyzes the metabolism of homocysteine is not functioning properly or the level of homocysteine is too low, so it needs to be improved by supplementing folic acid and B vitamins, so as to bring homocysteine back to the normal metabolism level, thus reducing the risk of cardio-cerebral and cerebral vascular diseases. Elevated homocysteine is a risk factor for cardiovascular and cerebrovascular diseases, which may lead to high blood pressure, coronary heart disease or cerebral infarction, etc. Therefore, it is necessary to go to the hospital in time for examination and treatment, and to carry out targeted treatment under the guidance of a professional doctor in combination with the individual’s condition, so as to avoid aggravation of the condition and adverse consequences.