In clinical practice, intestinal perforation surgery is a major surgery. Intestinal perforation is one of the surgical emergencies. In general, intestinal perforation will trigger patients to have pressure pain, rebound pain, muscle tension, diminished or absent intestinal sounds throughout the abdomen, and some patients will also experience nausea, vomiting, abdominal distension, fever and other discomforts. Once intestinal perforation occurs, it must be given sufficient attention because it can lead to diffuse peritonitis, resulting in infectious shock, and if infectious shock is not treated in time, the patient’s life is threatened. At this time, the patient must be given anti-infective treatment, and the patient’s blood volume must be expanded, and preoperative examination and preparation for surgery must be improved. Generally speaking, the surgical procedure depends on the size of the patient’s intestinal perforation. If the patient’s intestinal perforation is small, then a simple repair of the perforation is sufficient; however, if the patient’s intestinal perforation is large, then a resection of the intestinal segment should be done, followed by an intestinal anastomosis. In this way, the patient can recover smoothly.