Because the trigeminal nerve is located in the face, patients sometimes cannot distinguish the source of pain and can easily mistake it for toothache or headache, resulting in delayed treatment. Trigeminal neuralgia is very common in life, but there are many people who do not have a deep understanding of this disease. The biggest feature of this disease is that the pain on the affected side of the face is intense, like electric shock, knife cutting, needle stabbing, etc. It is easily triggered when washing face, brushing teeth, eating and talking, which really brings a lot of trouble to the patients’ life. What should we do when trigeminal neuralgia comes back repeatedly? Through a true story, we can find a cure for trigeminal neuralgia. He was diagnosed with “cerebral blood supply deficiency” in several hospitals and given oral medication (details unknown), but his symptoms did not improve significantly. One year ago, the above symptoms reappeared, and he took oral carbamazepine and gradually increased the dosage, but the symptoms did not improve significantly. He was treated with acupuncture, but there was no significant effect. The symptoms gradually worsened, and touching the skin of the eyes and nose could trigger pain, and the number of pain episodes increased and lasted longer. He came to the neurosurgery department for further treatment and was admitted to the hospital with “right trigeminal neuralgia”. After admission, he was admitted to the hospital with “right-sided trigeminal neuralgia”. After completing the relevant examinations, Professor Wang performed the right-sided trigeminal nerve microvascular decompression under general anesthesia on November 24, 2016. Postoperative treatment was given to prevent infection, stop bleeding, nerve nutrition and fluid replacement. Postoperatively, He’s right facial pain symptoms basically disappeared, and pathological reflexes were not elicited. After examination, it was indicated that He’s condition was stable and could be discharged. It can be seen that He’s trigeminal neuralgia has been repeatedly attacked for several years, from the initial medication control to the final medication is no longer effective, and finally chose microvascular decompression surgery treatment. Long-term untreated trigeminal neuralgia can easily cause a series of changes in the physiological activities of the body such as neuroendocrine, circulatory system, respiratory system and digestive system. Therefore, this disease needs to be treated thoroughly, which requires microvascular decompression surgery. So let’s learn more about the principle of microvascular decompression surgery for trigeminal neuralgia. Microvascular decompression surgery for trigeminal neuralgia has a history of more than ten years, and the current surgical technique is quite mature, with the characteristics of minimally invasive, safe and high efficiency. Most patients can be cured after surgery, and the chance of complications is very low. It is currently recognized as the best treatment for trigeminal neuralgia at home and abroad. Moreover, patients with milder symptoms and shorter history often have better treatment results. Some patients do not have timely surgical treatment due to the lack of corresponding medical knowledge, which delays the treatment time. Microvascular decompression can achieve a single radical cure, even if there is a delayed cure, and it is often not necessary to continue oral medication to relieve symptoms. The symptoms of spasticity disappear immediately after surgery in most patients. In only a few patients, a period of neurological recovery is required due to severe nerve damage, and symptoms gradually resolve during the recovery period.