Neuralgia can last from a few seconds to a few minutes and can stop suddenly or recurrently. Patients can have several or even dozens of episodes per day, and the pain can be stabbing, throbbing, or knife-like pain, which is more intense and may affect the patient’s daily life and work. The exact cause of primary neuralgia is unclear, while secondary neuralgia has a clear etiology, mainly due to nerve demyelination changes resulting in abnormal nerve discharge. Primary neuralgia clinically commonly includes trigeminal neuralgia, greater occipital neuralgia, temporal neuralgia and sciatica, and the location of pain varies among patients with different neuralgia. In case of secondary neuralgia, common clinical diseases include early brain tumor, which can also be caused if the patient has cerebrovascular disease, and also seen in multiple sclerosis, etc.