In simple cholecystitis, bilirubin usually does not show obvious elevation, but if combined with gallbladder stones to cause obstructive jaundice, bilirubin can be elevated. 1. Simple cholecystitis: the bilirubin of simple cholecystitis usually has no obvious abnormal changes, but if the bilirubin is elevated, the cause should be identified, which may be caused by hepatocellular jaundice caused by cirrhosis, hepatitis, hemolytic jaundice caused by hemolytic anemia, and so on. 2. Cholecystitis combined with gallbladder stones: when combined with gallbladder stones, the stones may press the common hepatic duct in the gallbladder duct or fall into the common bile duct. This will cause bile duct obstruction and bile stagnation, resulting in obstructive jaundice, which is manifested by elevated bilirubin, with elevated conjugated bilirubin as the main component and elevated unconjugated bilirubin as the secondary component. If bilirubin is elevated in cholecystitis, the cause of the elevation should be identified and treated promptly to avoid delaying the condition.