If a patient with advanced uremia cannot be treated with dialysis, the patient’s life may enter the countdown. The treatment at this time is mainly based on symptomatic treatment, conservative treatment and hospice care.1. Symptomatic treatment is based on the complications of the patient, such as hypertension, which can be treated with oral antihypertensive drugs or intravenous antihypertensive drugs.2. If the patient has disorders of the internal environment, such as hyperkalemia, metabolic acidosis, low calcium, high phosphorus, etc., the patient can be treated with oral drugs or intravenous fluids to lower potassium, correct acid, calcium and phosphorus. If the patient has anemia, he can use erythropoietin or iron supplements, folic acid, hematopoietic materials, and apply for blood transfusion therapy to correct the anemia if necessary. 4, if the patient has heart failure or arrhythmia, active anti-cardiac failure treatment. 5, if the patient has If the patient has gastrointestinal bleeding, it is necessary to suppress acid, stop bleeding and other symptomatic treatment. At the same time, after entering the advanced stage of uremia, attention should be paid to end-of-life care, and patients should be given cardiac monitoring, oxygen supply and other symptomatic treatments.