Korsakov syndrome, or alcohol-related amnesia syndrome, is one of the characteristic symptoms of chronic alcoholism. The most distinctive feature of Korsakov’s syndrome is the lack of memory of what has happened. Korsakoff syndrome occurs in patients who have been drinking alcohol for a long time and has a slow onset, often after one or more episodes of delirium tremens. The main manifestations are proximal amnesia, delirium, fictitious amnesia and retrograde amnesia, often with disorientation, especially temporal disorientation, but no significant impairment of perception and thinking, many patients may be accompanied by polyneuritis, myasthenia gravis and muscle paralysis, most chronic course, often persistent. Korsakoff syndrome has a poor prognosis and poor outcome. Treatment Its occurrence is related to thiamine deficiency, so it needs to be supplemented with large amounts of thiamine as soon as possible with 500-1000 mg intravenously, and thiamine supplementation must precede infusion, otherwise there can be worsening of symptoms. After the surprise intravenous injection, it can be changed to intramuscular and oral injection, along with multivitamin supplementation, especially niacin. Prognosis Because the disease develops from chronic alcoholic hallucinations and alcoholic delirium tremens, only a minority of people can gradually improve, some with polyneuritis, myasthenia and paralysis.