Leukoser’s syndrome is a systemic disease of currently unknown cause, pathologically characterized by small vessel vasculitis involving organs throughout the body. Leukoarai’s syndrome often leads to mouth ulcers, conjunctivitis, and genital ulcers, which is why it is also known as the oro-ocular-genital triad. Leukoaraiosis can be mild or severe, and there is no cure for the more severe forms of leukoaraiosis. However, treatment should be carried out with a positive mindset to alleviate the symptoms. Oral mucosal diseases symptomatic local application of drugs, the involvement of systemic organs can be treated with glucocorticoids, thalidomide, colchicine, new drugs lenalidomide, biologics, and immunosuppressants, eye diseases and the application of eyedrops for eye drop treatment.