Clinical treatment of hepatitis B is fundamentally an anti-hepatitis B virus therapy. At present, there are two major types of treatments: 1) oral nucleoside analog therapy; 2) injectable interferon-based therapy. There are six types of oral nucleoside analog drugs: lamivudine, adefovir, entecavir, telbivudine, tenofovir, and propofol tenofovir, and entecavir is most widely used to treat hepatitis B patients due to the factors of drug accessibility and price. With the launch of propofol tenofovir, it is favored for its high efficiency antiviral, few side effects, low incidence of liver cancer, and maintaining zero drug resistance so far. Injectable interferon therapy is categorized into regular interferon and polyethylene glycol interferon. Regular interferon is gradually being phased out due to its low efficacy and many side effects. PEG interferon, despite its many side effects, has been widely adopted because of its short course of treatment and high conversion rate.