Entecavir is not recommended for patients with hepatitis B mainly because this drug may cause significant adverse reactions, osteoporosis, as well as affect the blood and other factors. Entecavir can be used for long-term treatment of hepatitis B patients, as well as HlV-1 and hepatitis B virus co-infection of patients, but some patients are intolerant of the drug, or long-term use of the stock causes serious adverse reactions, need to adjust the treatment program. 1. Adverse reactions are obvious: some hepatitis B patients taking entecavir may induce dizziness, nausea, abdominal pain and other adverse reactions. Especially when the drug is just started, the adverse symptoms are usually more obvious. 2. Osteoporosis: if hepatitis B patients take entecavir for a long time may impair kidney function as well as osteoporosis and other conditions. The same type of propofol tenofovir does not have this situation, and anti-viral efficacy is also comparable to entecavir. 3. Affecting blood picture: Entecavir dispersible tablets may affect the measured values of white blood cells, hemoglobin, platelets, etc. in patients with hepatitis B. If physical examination is needed, the doctor should be informed in advance. The treatment of hepatitis B needs to be analyzed and treated according to the specific condition, and it is recommended that patients go to the hospital in time and choose the targeted treatment method under the guidance of professional doctors.