How many days a pimple can go down depends on the severity of the pimple rash and the appropriateness of the medication used. If the acne rash is mild, only the appearance of follicular inflammatory papules or pustules, can be applied after the topical clindamycin phosphate gel or fusidic acid ointment, 2-3 days to achieve the therapeutic effect of improvement or elimination. If the acne is more serious, with redness, swelling, pain and elevated skin temperature around the acne, it is necessary to take oral minocycline hydrochloride capsule or roxithromycin capsule, use the above drugs externally, and at the same time, can also be combined with the application of helium-neon laser topical irradiation, at least it takes at least about 7 days to achieve the effect of improvement or subsidence.