It is best not to break the blisters on the foot. The wall of the blisters protects the trauma for better recovery, and it is recommended to wear loose, soft and comfortable shoes to avoid frictional stimulation. If you accidentally break the blister, it is recommended to use povidone-iodine solution or iodophor solution locally to clear the wound to avoid infection and affect healing. If the blisters are due to eczema, topical glucocorticoid creams, such as Denide and Mometasone Furoate cream, can be applied topically. If the blisters are due to fungal infection, topical antifungal bifenoconazole cream, liraglutide cream, etc. can be given. It is recommended not to break the blisters to avoid limited wound healing, and be sure not to touch the water to avoid infection. If the blisters are caused by frictional irritation, they can usually dry up, crust and fall off on their own.