There is no such thing as the most effective medication to use for nasal boils, and antibiotic medications are usually required, including topical and systemic medications. Nasal boils are mainly due to an acute suppurative inflammation caused by Staphylococcus aureus infection. In the early stage when it has not yet developed, it can be applied locally with antibiotic ointment, such as erythromycin ointment and gentamycin ointment, which can promote anti-inflammation and relieve the pain, and it can be accompanied by oral antibiotic medication, such as roxithromycin and azithromycin. If the nasal boil has broken on its own, disinfect the area with iodine povidone and then apply antibiotic ointment. If the boil does not burst on its own, it cannot be treated with medication alone, and the inoculation needs to be incised and drained and treated with routine anti-infective therapy. Nasal boils should always be medicated by a doctor, not on your own, and especially not with antibiotics.