There are two main purposes of having cranial repair surgery for cranial defects, one is for safety and the other is for aesthetics. The choice of repair material for cranial bone repair surgery is also crucial. If the patient chooses a repair material that is not ideal, it may produce rejection and postoperative infections, leading to the removal of the patient’s repair material and failure of the surgery. Cranial defects do cranial repair surgery better time, for the wound is relatively clean open skull comminuted fracture, no cranial hypertension patients, it is recommended that a phase of cranial repair surgery. For patients with severe closed craniocerebral trauma, giant skull defects caused by cranial hypertension due to decompression of the large bone flap should be repaired about three months after the defect. At present, a few regular hospitals have chosen the new PEEK material as the cranial bone repair material, PEEK material to do cranial bone repair is better than the traditional repair material, and the preoperative is based on the shape of the patient’s cranial defect through the 3D printing, the appearance of the appearance and the previous no difference. Cranial bone repair using PEEK as a repair material, through clinical practice found that PEEK material low density, insensitive to temperature, have high tissue stability, so that it can be sterilized at high temperatures or radiation does not produce deformation. And through a large number of clinical feedback found that PEEK material has ray transmissibility, CT and MRI results will not have an impact.