The problem of cranial defect should not be taken lightly, if it is not treated in time, it will lead to a series of neurological dysfunction problems, and also induce some syndromes, such as dizziness, nausea and fear of cold, limb muscle weakness and other symptoms. There are also cranial defects can lead to severe cerebral edema, resulting in localized ischemic necrosis of the brain, causing a variety of neurological localization symptoms. Therefore, once the cranial defect occurs, timely examination and treatment in regular hospitals is the key. In the process of cranial repair surgery, there are many factors affecting the postoperative results, such as the time of surgery, the hospital chosen, experts and materials, etc.. Generally speaking, most of the cranial injuries caused by trauma or surgery, etc., should be carried out after three months before cranial bone repair surgery. As for the materials for skull repair surgery, there are a lot of materials in medicine, such as plexiglass in the early stage, bone cement, titanium alloy and so on in the later stage. However, after a series of clinical verification shows that these ordinary materials have certain defects, and patients will have various physical rejection reactions after surgery, so in order to better achieve good results after surgery, it is very necessary to choose a safer material. In the choice of cranial bone repair material, the new PEEK material, more secure and advanced, hard and flexible, not easy to deform. This PEEK material can be very good heat insulation, strong stability, can be three-dimensional molding, anastomosis is extremely high, is currently doing cranial bone repair surgery material.