The combination of amlodipine and irbesartan is possible to treat high blood pressure. Amlodipine is a calcium channel blocker, which mainly reduces blood pressure by decreasing myocardial contractility and dilating blood vessels. Irbesartan is an angiotensin II receptor antagonist, which mainly reduces blood pressure by blocking the vasoconstrictive effect of angiotensin on blood vessels. The blood pressure lowering mechanisms of the two are different, and the combined use of drugs can play a synergistic effect of lowering blood pressure, so it is possible to use together. Amlodipine to reduce blood pressure at the same time, may cause sympathetic excitation, reflex induced accelerated heart rate, resulting in panic, peripheral edema and other adverse reactions, and Irbesartan can just offset, so their combined use can also play a role in reducing the effect of adverse reactions. It should be noted that the drug treatment of hypertension must be under the guidance of a specialist physician, according to the level and characteristics of hypertension for drug selection, do not use drugs indiscriminately.