Rabies is a zoonotic acute infectious disease caused by rabies virus, widespread, with a very high mortality rate, and its typical clinical manifestation is hydrophobia, so rabies is also known as hydrophobia. The initial stage is sensitive to sound, light, wind and other stimuli and tightening of the throat, into the excitement phase can be manifested as extreme terror, fear of water, fear of wind, episodes of pharyngeal muscle spasms, respiratory distress, etc., and finally the spasms stop and a variety of paralysis, can quickly die due to respiratory and circulatory failure. Rabies vaccine is given to people who have been bitten or scratched by animals to prevent rabies infection. After receiving the rabies vaccine, people are often told to eat lightly, avoid spicy food, alcohol and tea, and even not to eat “hairy food (fish, shrimp, crab, beef and mutton, etc.)” as this can lead to serious consequences. Is there really a scientific basis for all these recommendations? Is it necessary to avoid eating after vaccination? If not, how serious are the consequences? For this reason, it is important to know the following information. Rabies vaccine instructions require: avoid drinking alcohol, strong tea and other stimulating foods and strenuous exercise, etc. 1. Rabies vaccine instructions from the Pharmacopoeia of the People’s Republic of China Before 1980 in China, rabies vaccine was produced with animal brain tissue, with many vaccination shots and large vaccination doses, plus the vaccine at that time was not purified and contained many impurities, so the side effects were great, and behaviors such as drinking alcohol and strenuous exercise could Therefore, the instructions of the vaccine at that time clearly stated: “Do not drink alcohol, drink strong tea and eat stimulating food, and avoid catching cold and flu or strenuous exercise or labor. With the advancement of technology, the rabies vaccine is now cultured with cells and concentrated and purified, and the rate of adverse reactions has been greatly reduced, but the 2015 edition of the Pharmacopoeia and some manufacturers’ instructions still continue the previous content, yet there is no experimental basis to state that the rabies vaccine currently in use should retain the above contraindications regarding diet and exercise. The WHO rabies-related documents have never mentioned any contraindications to diet and exercise, and no scientific basis for such dietary or exercise restrictions can be found in the available literature at home and abroad. Therefore, dietary and exercise restrictions for rabies vaccination are not necessary. These dietary and exercise restrictions may be observed, but they should not be taken too seriously. After vaccination, if you drink alcohol or eat spicy hotpot, etc., there is no need to worry if you do not experience serious physical discomfort, as these diets or sports will not cause immunization failure or other serious consequences. Of course, some people who are allergic to certain foods or alcohol should avoid contact with them during vaccination, otherwise it is impossible to determine whether it is a dietary problem or an adverse reaction to the vaccine if an allergic reaction occurs.