High total bile acids in newborns are commonly found in hemolytic jaundice, viral infection, congenital biliary atresia and other diseases. 1. When the baby’s hemolytic jaundice is severe, both indirect bilirubin and direct bilirubin will be increased, and even cholestasis and high bile acid; newborn hemolytic jaundice is mainly caused by incompatibility of blood groups of the mother and the fetus, which may be ABO hemolysis or RH hemolysis. Newborns may have marked jaundice and hemoglobinuria. 2. The presence of viral and bacterial infections in the baby causes liver function impairment, when bile excretion is not smooth, it will be secondary to cholestasis, causing high bile acids. Such as viral hepatitis, especially hepatitis B or C, mainly through mother-to-child transmission. 3. Congenital biliary atresia is a congenital disease closely related to congenital biliary dysplasia and cytomegalovirus infection, with a poor prognosis. The presence of inborn genetic metabolic diseases in babies can also cause high bile acids. Therefore, if a newborn baby has high bile acid or jaundice, he should go to the hospital in time to check the cause of the disease and then carry out the relevant treatment.