There is no necessary connection between the amount of bilirubin and whether or not artificial liver therapy is performed. Artificial liver treatment refers to the use of special instruments or biological devices, imitating the metabolism and detoxification function of the liver, purifying human blood, removing all kinds of harmful substances, improving the internal environment, and creating the conditions for regeneration of liver cells, recovery of liver function, and liver transplantation. Generally, artificial liver can be treated if there is obvious elevation of bilirubin, failure of liver function as well as chronic hepatic dysfunction in which the patient has failed to undergo treatment. When the bilirubin is high, blood can be drawn and the corresponding examination work can be done, and if the liver index is normal, there is no need to do artificial liver treatment. In the clinic, artificial liver treatment is only as a kind of alternative treatment, and cannot achieve the fundamental therapeutic effect, and ultimately cannot or is very difficult to achieve the purpose of curing liver failure. When the bilirubin is obviously elevated, timely examination should be carried out, and targeted treatment under the guidance of the doctor.