Inoperable endometrial cancer in advanced stage is mainly caused by extensive metastasis and physical weakness, and the treatment is still based on radiotherapy, chemotherapy and targeted therapy. Patients with advanced stage endometrial cancer have already had metastasis and spread of distal organs and lymph nodes, and there are many lesions, so it is difficult for surgery to remove all the tumors, and surgery is not very useful and meaningful. Secondly, endometrial cancer belongs to consumptive disease, patients in advanced stage have consumed a lot of energy and nutrients, and their bodies are in a highly weakened state, which makes it difficult for them to bear the damage brought by surgery, therefore, they cannot undergo surgical resection. Therefore, surgical removal is not possible. For patients with advanced endometrial cancer, radiotherapy, chemotherapy and targeted therapy are mainly used to help improve their quality of life and prolong their survival cycle. Patients with advanced endometrial cancer should not give up the treatment, and should adopt targeted treatment according to the situation under the guidance of doctors.