Raynaud’s syndrome is more common in women, and the onset of the disease is generally slow, beginning with transient episodes mostly in the winter, but the severity and duration of symptoms increase as the disease is delayed. The clinical symptoms of Raynaud’s syndrome are generally manifested in three periods. i. Ischemic period. It generally occurs in the fingers, toes, and distal skin, with episodes of pallor, stiffness and coldness, with sweating, numbness and pain, usually mostly symmetrical, starting to progress to the palm of the hand, but rarely beyond the wrist. Second, the anoxic phase. The affected area continues to be ischemic, with capillary dilation and bruising, cyanosis and purple skin, low skin temperature and pain, at which time the self-conscious symptoms are generally mild. Third, the congestion period. Generally after the warmth can occur automatically, at this time the vasospasm is released, the arteries are congested, the skin is flushed, the skin temperature rises, there may be tingling, swelling and mild throbbing pain.