When cancer reaches advanced stage, besides unclear speech spitting, there is also the possibility of complete inability to speak or unconsciousness. It may be due to advanced severe malnutrition and a state of cachexia, or it may be a malignant cancer cancer with intracerebral metastasis, which affects pronunciation or other consciousness aspects, and its suggests that there is no effective treatment for the disease progression. If brain metastases are identified, radiotherapy can be considered to control the development of the disease, and for symptoms such as increased intracranial pressure, dehydrating and cranial pressure-lowering drugs such as mannitol can be applied to treat the disease. There is no way to reverse the disease of advanced cancer, only to treat symptomatically to reduce the patient’s pain and prolong the survival period.