The large amount of menstruation with a large number of blood clots, usually due to endometrial hyperplasia and other diseases, commonly used therapeutic drugs are ethinyl estradiol cyproterone tablets, progesterone capsules, medroxyprogesterone acetate tablets, aminomethyl cyclamic acid tablets, etc., specific medication should be in accordance with the doctor’s instructions, not blindly self-medication. The use of short-acting oral medications such as ethinyl estradiol cyproterone tablets and drospirenone ethinyl estradiol tablets can inhibit the secretion of the hypothalamus-pituitary-ovarian axis, thus improving the symptoms of heavy menstruation with large amounts of blood clots caused by endometrial hyperplasia. These medications are more suitable for women in their reproductive years who require contraception. Treatment can also be carried out with progesterone capsules, medroxyprogesterone acetate tablets and other monoprogesterone, which are useful in reducing the effect of estrogen on the endometrium and alleviating the symptoms of heavy menstruation with blood clots caused by endometrial hyperplasia. These medications are indicated for women in puberty or menopause. In addition, some hemostatic drugs, such as tranexamic acid tablets, can also be used in the treatment of heavy menstruation and are suitable for cases of heavy menstruation with blood clots caused by strenuous exercise during menstruation, for example. Patients with heavy menstrual flow accompanied by a large number of blood clots should consult a doctor in time, who will choose the most suitable and effective medication according to their condition and physical status.