Ibuprofen is not recommended for liver transplantation. Ibuprofen is an antipyretic and analgesic, non-steroidal anti-inflammatory drug, mainly used for the relief of mild to moderate pain, such as headache, toothache, muscle pain, menstrual cramps and so on. Ibuprofen is mainly metabolized by the liver and then excreted through the kidneys, and its use needs to be prohibited for people with severe hepatic and renal insufficiency. Liver transplantation is generally the treatment for patients with end-stage liver disease, and complications such as metabolic disease, rejection reaction, and renal disease are the main causes of long-term mortality in liver transplant patients. Patients with liver transplantation need to take immunosuppressants and anti-infective drugs for life. During the medication period, they need to take the drugs strictly on time and as prescribed by the doctor in order to reduce the rejection reaction after liver transplantation and prolong the survival period of liver transplantation. Patients with liver transplantation are generally not recommended to take non-steroidal anti-inflammatory drugs such as ibuprofen, so as not to affect the effect of immunosuppressants, rejection reactions, or even damage the kidneys and cause serious complications. Patients with liver transplants should consult their doctors in advance before taking any other drugs to avoid serious adverse reactions. In addition, liver transplant patients should strengthen physical exercise and eat a light diet with high calcium, low fat and low sugar.