Uric acid below 80 μmol/L may be harmful, such as easy to induce acute kidney injury, urinary tract stones, chronic renal failure, neurological damage, cardiovascular system damage. Hypouricemia refers to the serum uric acid concentration is less than 120 umol / L, the causes include hereditary xanthinuria, purine nucleoside phosphorylase deficiency, and the impact of drugs caused by reduced uric acid production; renal hypouricemia, Fanconi syndrome, drug-induced increase in uric acid excretion. Hypouricemia often has no obvious symptoms, but a large number of studies have shown that hypouricemia affects multiple systems and causes harm, including acute kidney injury, urinary stones, chronic renal failure, neurological damage, cardiovascular system damage. At present, for hypouricemia, patients without obvious symptoms generally do not need special treatment, regular rechecking of blood uric acid levels, avoid strenuous exercise; if systemic damage requires targeted treatment. It is recommended that patients go to the hospital in a timely manner, complete the relevant examinations under the guidance of the doctor, identify the causes, and follow the doctor’s instructions to avoid adverse consequences.