Hepatitis B antiviral drugs do not have any special requirements on when to take them, as long as they are taken on an empty stomach, any time of the day is fine. Hepatitis B antiviral drugs include entecavir, tenofovir disoproxil fumarate, tibivudine and so on, in order to ensure better absorption of the drug, required to be taken on an empty stomach, so it is generally taken before or 2 hours after meals, it is recommended to choose to take before bedtime, when the stomach is in a state of emptying, and the time until the next meal is also longer, which is conducive to the absorption of drugs. If the patient has gastrointestinal dysfunction, should pay attention to light diet during the medication, try to avoid spicy and stimulating food, if there is gastric discomfort, but also with some gastric drugs, such as omeprazole enteric-coated capsules, magnesium alumina carbonate chewable tablets and so on. During the period of taking antiviral drugs, it is necessary to pay attention to the dosage for people with renal insufficiency, liver transplant recipients, etc., and closely monitor the function of liver and kidney, in addition, the antiviral drugs can not reduce the risk of transmission of hepatitis B virus through sexual contact or contaminated blood, so it is necessary to take protective measures during the period of taking the drugs. Antiviral drugs are contraindicated in people who are allergic to their ingredients. Adverse effects such as dizziness, fatigue and nausea may occur. Antiviral drugs should be taken under the supervision of a medical professional.