Pain in the ankle like a sprain needs to be ruled out firstly as a traumatic factor and secondly as an acute gouty attack, acute synovitis. 1. Traumatic factors: ligament injuries, ankle fractures, or soft tissue injuries caused by sprains and other factors will often cause ankle swelling and pain, the patient may wake up in the morning the next day when the swelling and pain aggravated, often due to the lack of attention to the braking at night, or improper posture triggered by the aggravation of pain. 2. Acute attack of gout: most of the acute attack of gout is triggered by improper diet and other factors, most of the patients have a history of gout, and the ankle pain occurs after eating seafood and other high purine-containing foods. 3. Acute synovitis: synovitis often occurs due to high activity, infection, cold, etc. In addition to localized redness, swelling, heat and pain, there will also be ankle joint effusion. For sudden pain and discomfort in the ankle joint, it is necessary to consult the hospital in time, under the guidance of the doctor to clarify the cause of the disease and carry out targeted treatment.