Nursing diagnosis of acute lymphoblastic leukemia mainly includes prevention of infection and care for related complications with cleanliness and hygiene, dietary habits, and special medication. Acute lymphoblastic leukemia is a kind of acute leukemia, which mainly originates from B-lineage or T-lineage lymphoid progenitor cells. Leukemia cells abnormally proliferate and aggregate in bone marrow, thus inhibiting normal hematopoiesis and leading to anemia, thrombocytopenia and neutropenia. 1. Cleanliness and hygiene: patients should develop good hygienic habits, such as daily oral cleansing care, paying attention to regular cleaning of hands, perianal area, perineum and trunk area. 2. Dietary habits: patients are advised to have a light diet, pay attention to balanced nutrition, should not eat cold food, try to consume easily digestible food, avoid too greasy, indigestible food and thin-skinned fruits. 3. Special medication: Acute lymphoblastic leukemia is usually treated with molecularly targeted drugs, such as TKI agents and methotrexate, which are suitable for patients who have achieved complete remission.