Total bilirubin 25.4 is not necessarily a problem. If it is a physiological increase caused by prolonged alcohol consumption or strenuous exercise, the problem is not too serious; if it is an increase caused by hepatitis and other pathologic factors, it is a problem. Total bilirubin is the sum of direct bilirubin and indirect bilirubin, and the normal reference value is 5.13-22.4 mmol per liter (0.3-1.3 mg per deciliter), which is usually measured by drawing venous blood after 12 hours of fasting. Determination of serum total bilirubin is an important test in liver and biliary function tests. High total bilirubin can be caused by diseases such as toxic hepatitis, hepatocellular jaundice, and viral hepatitis. These diseases can cause damage to liver cells, which makes it difficult for bilirubin to be converted in the liver. They can also cause pressure on the intrahepatic bile ducts, which interferes with the normal excretion of bile, resulting in an elevation of direct or indirect bilirubin, which leads to an elevation of total bilirubin. The total bilirubin is 25.4. It is recommended to consult a doctor for a clear diagnosis and to carry out targeted treatment under the doctor’s guidance.