Olmesartan ester amlodipine is taken once a day and it is a long-acting formulation. Olmesartan amlodipine is a combination of olmesartan ester and amlodipine. Olmesartan ester mainly through the inhibition of angiotensin II receptors to play a role, amlodipine mainly inhibit calcium ion convection, with peripheral vasodilatation and lowering the effect of blood pressure. Olmesartan ester amlodipine has a long half-life, and can be taken once a day to maintain effective blood concentration, and play a long-lasting antihypertensive mechanism. Patients with high blood pressure should try to use a long-acting preparation and take the drug once a day to avoid significant fluctuations in blood pressure levels. Adverse reactions such as edema and headache may occur after using the drug. Patients with severe hepatic insufficiency and breastfeeding women should not use this drug. Patients who need to use the drug should do so under the supervision of a doctor.